Americans and Russians are stranded aboard a damaged space station. A rescue crew is sent from earth, including Carpenter (Michael Dudikoff) and Jack McKendrick (Hannes Jaenicke). When attempting to return to earth, the astronauts find that the reentry codes have been changed. While the astronauts are helpless and stranded, Jeffries (Ice-T) pursues a Russian man who knows the new codes.
电影讲述了经历精神创伤的陈教授突然失踪，美国警方查找无果，Shirley杨求助胡八一和王胖子同她前往云南寻找教授。胡八一、王胖子、Shirley杨等人一路遭遇食人鱼、千年痋术、变异巨型蜘蛛等千“虫”万险。在试图寻找陈教授的过程中，更是与吴大卫带领的盗墓团伙正面交锋，在历经层层凶险后，众人终于来到献王墓，然而更大的危机也接踵而至……
