本剧由《绝命毒师》《风骚律师》主创文斯·吉里根打造，《风骚律师》蕾亚·塞洪主演，是一部打破类型界限的科幻剧集，讲述地球上最痛苦的人必须将世界从「幸福」中拯救出来。蕾亚·塞洪饰演一位情感麻木的历史言情小说畅销作家卡罗尔，她自嘲作品是“无脑的垃圾”。正当她为新书展开巡回宣传之际，一股神秘现象席卷新墨西哥州的宁静小城阿尔伯克基：一种末世病毒（或许并非末世，这取决于你的询问对象）向全世界强行灌输了乐观与满足。
This drama is set in a south Florida plastic surgery center, McNamara-Troy, centering around the two doctors who own it. Sean McNamara (Dylan Walsh) is having problems at home, trying to keep his family together, trying to patch up the rocky road him and his wife Julia (Joely Richardson) are experiencing. On the other hand, sex-craved Christian Troy (Julian McMahon) uses his charm to bring in potential female candidates and conducts shady business deals, often for the love of money. While Sean takes his job seriously, he often has to fix Christian's mistakes. During the first season, Sean and Christian got mixed up with Escobar Gallardo, a Colombian drug lord who forced the two to do free surgery whenever he wanted them to. Sean's marriage with Julia began to wear thin, and Sean had an affair with a patient named Megan O'Hara. Julia went back to school, but it was interrupted by a miscarriage of a child Sean and Julia were trying to have. Christian learned he is the father of a baby with a woman named Gina, who he met at Sexaholics Anonymous. When the baby was born, we learn that the baby is African-American, and therefore not his. Julia questions Matt's paternity.
《使女的故事》第二季确定2018年4月回归，总共会有13集。
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