影片将故事设定在一列通勤列车上，一位十年如一日乘坐列车上下班的商界人士麦考利（连姆·尼森 饰），偶遇一位主动搭讪的“神秘乘客”乔安娜（维拉·法米加 饰）。乔安娜为麦考利提供了一个极具诱惑性的任务——找出车上的一位乘客，即可获得一笔巨额现金作为回报。但在寻找的过程中，麦考利逐渐发现自己卷入到一场致命的危险处境中。 他是否能够从这辆“恐怖列车”中成功逃脱，背后又隐藏着怎样的惊天阴谋。随着列车不断加速，真相逐一揭开......
Firenze's leading, very wealthy jewelers family heir Francesco Sabrini received a cryptic death treat on the back of a renaissance painting in their private attic collection. A masterly forgery was offered in Fabio Milus's Roman auction house, but German-born art expert Susanna Noll kept it back for investigation in he artist's home city, Florence, to consult her art history mentor, professor Andreas von Weissenfels. There she stays with friend Elisabeth Lanzi, who introduces here to Francesco and his family. During their research, which unearths modern crime with a link to a Renaissance-rumored fratricide, initially secretive Francesco and Susanna become lovers
